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The Creative Destruction of Medicine: How the Digital Revolution Will Create Better Health Care
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Review
Misha Angrist, Assistant Professor, Duke Institute for Genome Sciences & Policy, and author of Here is a Human Being“Eric Topol is that rare physician willing to challenge the orthodoxies of his guild. He recognizes that in the U.S., health care business-as-usual is unsustainable. But he does not despair. He bears witness to the rise of Homo digitus and the promise it holds to upend the inefficiencies and dysfunction so entrenched in clinical medicine. The Creative Destruction of Medicine is a timely tour de force. It is a necessary heresy.” George Church, Professor of Genetics, Harvard Medical School“What happens when the super-convergence of smart phones further combines with million-fold lower-cost genomics and diverse wearable sensors? The riveting answer leads compellingly to a call to activism—not only for medical care providers, but all patients and everyone looking for the next ‘disruptive' economic revolution. This future is closer than most of us would have imagined before seeing it laid out so clearly. A must-read.” Arnold S. Relman, New York Review of Books“As an introduction for the lay reader to the sophisticated digital technology now being applied to medical care, and as an explanation of the rapidly advancing science of medical genetics and the new revelations from the sequencing of the human genome, Topol's book is a tour de force.”Siddhartha Mukherjee, author of The Emperor of All Maladies: A Biography of Cancer“[A]n eye opening account of why conventional medicine is doomed…. [C]ompelling stuff…. [T]he book provides an excellent summary of the current state of medical genetics and how fast it is progressing, with examples that may surprise even those working in medicine.” Wall Street Journal“The Creative Destruction of Medicine—an allusion to economist Joseph Schumpeter’s description of ‘creative destruction’ as an engine of business innovation—is a venture capitalist’s delight, describing dozens of medical technologies that show great promise. The book also provides colorful anecdotes about Dr. Topol’s own sampling of these products, as both a doctor and stand-in patient…. [The book’s] most important contributions are in portraying how medical innovation will coalesce to change clinical practice and what the coming changes mean for today’s policy debates…. In Dr. Topol’s vision, innovation that enables real-time diagnosis and personalized treatments is a certainty, though not because reluctant or ‘sclerotic’ doctors accept it or because Washington wills it into being. A seductive technology that works like a dream and improves lives will set off a consumer clamor, whether the new tool is an iPhone 4S or an implantable blood-sugar meter.” “Eric Topol offers a new and intriguing perspective on how the intersections of medicine and technology could further transform the delivery of healthcare and the role of a patient. He advocates for a future world of medicine where informed consumers are in the driver seat and control their own healthcare based on genomic information and real-time data obtained through nanosensors and wireless technology.” Eric Silfen, M.D., Senior Vice-President and Chief Medical Officer, Philips Healthcare“In an upbeat, comprehensive volume, Dr. Topol has woven the prevailing technological undercurrents of the post-PC world—its power of many; its Gucci of gadgets; its cloud ecosystem; its ‘Arab Spring’ of apps; and its ubiquitous, calm computing—with the disruptive innovations of biomedicine, to create a compelling account of how this bio-digital transformation will hasten personalization of the highest quality of medical care.” Greg Lucier, CEO, Life Technologies“Dr. Topol is the top thought leader in medicine today, with exceptional vision for how its future can be rebooted. This book will create and catalyze a movement for the individualization and democratization of medicine—and undoubtedly promote better health care” Reed Tuckson, M.D., Executive Vice President and Chief of Medical Affairs, UnitedHealth Group“Eric Topol has written an extraordinarily important book at just the right moment. Drawing upon a unique and impressive array of convergent expertise in medical research, clinical medicine, consumer and health technological advancements, and health policy, Dr. Topol opens the door for an essential discussion of old challenges viewed through an innovative lens. In the context of increasingly unaffordable health care costs, suboptimal quality of care delivery, a tsunami of preventable chronic illness, and new accountabilities for consumer's health choices and behaviors, this book helps all of us to think about solutions in new and exciting ways!” Juan Enriquez, Managing Director, Excel Venture Management, and author As the Future Catches You“Much of the wealth created over the last decades arose out of a brutal transition from ABC's to digital code. While creating some of the world's most valuable companies, this process also upended whole industries and even countries. Now medicine, health care, and life sciences are undergoing the same transition. And, again, enormous wealth will be created and destroyed. This book is a road map of what is about to happen.” Dean Ornish, M.D., Founder and President, Preventive Medicine Research Institute, and author of The Spectrum“Eric Topol is the perfect author for this book. He has a unique understanding of both genomics and wireless medicine and has a remarkable track record as a charismatic pioneer, visionary, and change agent in medicine. I’m sure this book will reach a very large number of people with information that can both empower and help transform their lives for the better.” Nature“The digital age opens up the possibility of a new type of medicine in which an individual’s health data are digitized using wearable sensors, smartphone apps and genome information, writes geneticist and cardiologist Eric Topol. With this wealth of data, medical interventions could be tailored to our uniqueness. Topol covers failures in patient information; what might happen if genomics, imaging, sensors and better health information were to converge; and the potential pitfalls of this brave new medical world.” New ScientistJ. Craig Venter, Chairman and President, J. Craig Venter Institute“Our sequencing of the human genome eleven years ago was the beginning of the individualized medicine revolution, a revolution that cannot happen without digitized personal phenotype information. Eric Topol provides a path forward using your digitized genome, remote sensing devices and social networking to place the educated at the center of medicine.” Omar Ishrak, Chairman and CEO of Medtronic“Eric Topol provides an excellent and pragmatic view of the U.S. healthcare system from a patient's perspective. He then offers, through numerous examples, an exciting vision for the future ... when technology can be used to dramatically improve the quality of care and reduce cost at the same time. The Creative Destruction of Medicine is a highly informative and enjoyable book, which truly triggers the reader's imagination as to what is possible” Elias Zerhouni, M.D., President, Global R&D, Sanofi and former director, National Institutes of Health“If we keep practicing medicine as we know it today, healthcare will become an unbearable burden. We are in a real race between healthcare innovation and the resistance to change of the medical system. In a comprehensive and well researched tour de force, Eric Topol, always a clear and uncompromising thought leader of his generation, challenges us to imagine the revolutionary potential of a world where medical information no longer belongs to a few and can be automatically collected from the many to greatly improve healthcare for all. This is a must read!”Kirkus Reviews“Topol weaves useful knowledge about how to evaluate the choices open to patients into this exciting account of the revolutionary changes we can expect.”William R. Brody, M.D., Ph.D., President, The Salk Institute for Biological Studies“The Creative Destruction of Medicine is an engaging look into how the discoveries in genetics and biology will change the landscape of medicine. Along the way, Dr. Topol provides a fascinating compendium of stories about the shortcomings of medicine as it is currently practiced and how the revolutionary discoveries coming since the first sequencing of the human genome a decade ago will shape the delivery of healthcare in the 21st century.”“What happens when you combine cellular phone technology with the cellular aberrations in disease? Or create a bridge between the digital revolution with the medical revolution? How will minute biological sensors alter the way we treat lethal illnesses, such as heart attacks or cancer? This marvelous book by Eric Topol, a leading cardiologist, gene hunter and medical thinker, answers not just these questions, but many many more. Topol's analysis draws us to the very frontlines of medicine, and leaves us with a view of a landscape that is both foreign and daunting. He manages to recount this story in simple, lucid language—resulting in an enthralling and important book.” Atul Gawande, M.D., author of The Checklist Manifesto“Dr. Eric Topol is an extraordinary doctor. He's started a leading medical school, identified the first genes to underlie development of heart disease, led major medical centers, and been a pioneer of wireless medicine. But he is also a remarkable communicator—one of the few top-flight scientists in medicine to be able to genuinely connect with the public. He was, for example, the first physician researcher to question the safety of Vioxx—and unlike most who raise safety questions, actually succeed in bringing the concerns to public attention. I have known and admired Dr. Topol for a long time. I recommend him highly.” Paul E. Jacobs, Ph.D., Chairman and CEO, Qualcomm Incorporated“Dr. Topol believes that medicine, catalyzed by extraordinary innovation that exploits digital information, is about to go through its biggest shakeup in history. His newest book calls for a ‘jailbreak’ from the ideas of the past. In the next phase of medicine, powerful digital tools including mobile sensors and advanced processors will transform our understanding of the individual, enabling creative ‘mash-ups’ of data that will spark entirely new discoveries and spawn ultra-personalized health and fitness solutions. And with over 5.7 billion mobile connections worldwide, the mobile technology platform will have a major impact on that vision—leading to what Dr. Topol describes as nothing less than a ‘reboot’ of the health care system. Qualcomm, and its partners all around the world, are working to bring wireless innovations to market that will contribute to the solution. And we share Dr. Topol’s view that individual consumers have the opportunity, and the power, to increase the pace of the titanic change that’s coming.” John Martin, Chairman and CEO, Gilead Sciences
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About the Author
Eric J. Topol, M.D., is professor of innovative medicine and the director of the Scripps Translational Science Institute in La Jolla, California. Trained at Johns Hopkins University, he conducted one of the first trials of a genetically engineered protein for treating heart attacks, and was the founder of the world's first cardiovascular gene bank at the Cleveland Clinic. He lives with his family in La Jolla, California.
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Product details
Hardcover: 320 pages
Publisher: Basic Books; 1 edition (January 31, 2012)
Language: English
ISBN-10: 0465025501
ISBN-13: 978-0465025503
Product Dimensions:
6.1 x 1.1 x 9.2 inches
Shipping Weight: 1.2 pounds (View shipping rates and policies)
Average Customer Review:
4.3 out of 5 stars
204 customer reviews
Amazon Best Sellers Rank:
#434,046 in Books (See Top 100 in Books)
Given all the havoc that has beset the medical market it is no surprise that Topol has called this a "Creative Destruction of Medicine". The medical system in place from (say) the mid-20th century forward, will not be able to handle the continual flow of retiring baby boomers, let alone senior citizens with ever increasing life expectancies. Like so many promises made over the past years, in its present form medicine will not be able to afford to honor the Medicare entitlement. So the current system must be replaced it with something else that will work.The only good news is that the cost of medicine can be greatly reduced through the aggressive introduction of advanced cutting-edge technology. Topol provides examples of where the injection of a little technology can substantively improve medicine, and at the same time do so at reduced costs. We might be seeing what others in the past have called "inflection points", where radical improvements and changes lead to measurably better patient outcomes.Changes on the cusp, are by no means painless. In the future you personally will be unlikely to get nearly as much one-on-one time with your doctor. Instead you will be seen by other medical professionals like physician assistants, nurse practitioners, and technologists of all stripes . In writing this, I remember the days when my dentist actually cleaned my teeth (!). Now a hygienist tends to that, with the dentist stopping by to take a quick look and shake hands.It would seem the dentists got to the answer faster than medical doctors were able to:Delegate anything and everything you can to less expensive staff so you can see more patients and reap the rewards of an expanded practice.
It is impossible to overstate the importance of Dr. Eric Topol's book and his message. While the text is sometimes more technical than the average reader might be at ease with, the message that health care is endangered is vital to everyone. Politicians have refused to deal honestly with the health care lobby, the biggest and most powerful lobby in America, because its money means votes. As the Baby Boomers retire at the rate of 10,000 a day between now and 2019, the debt of health care -- already a $2.8 trillion monster -- is absolutely going to spiral out of control because nothing was done. My children, and their children, will be pinned under this financial burden their entire lives.Topol has reformative ideas and is busy employing them with real patients. His work in wireless medicine, where multimillion-dollar medical devices have been been reduced in size and expense -- some to the size of a smartphone -- could not only save billions every year in hospital charges, but re-establish the patient-physician relationship that has been lost.Dr. Topol's ideas need to be heard by everyone because the patient of tomorrow will have to be conversant in health care, lest they become one of the 50 percent of bankruptcy filers who do so because of medical bills.
This book is a must for ANYONE who will ever be part of the health care system (as a provider or recipient of health care). Dr. Topol has written this book for the empowered consumer but as a physician who spent a career focusing on quality of care, I found it enlightening and fascinating. Dr. Topol takes us from the population based/guideline based medicine of today (WHEN we are lucky enough to have enough population based evidence for guidelines) to the individualized medicine of the not too distant future and explains how genomics and digitalization will make that possible. There are so many useful aspects to this book including a discussion of how to interpret the literature, how to evaluate the internet as a resource, how to select a top notch doctor and what kinds of conditions that is important for and so much more. Just to find about the MIT OpenCourseWare was worth the price of the book. This book is a major contribution from a doc who has been one of the major contributors to health care in this country. It was recommended to me by a cardiologist friend and I have recommended it to everyone from doc friends to musician friends. Lots of important content written with great clarity in a personal, almost conversational style that makes it a pleasure to read.
Wow Dr. Topol became a role model for me after I read this book.It just sucks that the average person interested in health isn't going to be able to read this book, nor are ideas like this the impetus for social change, because unfortunately complicated ideas from smart people aren't understood by most and thus don't go anywhere without social media efforts and popularity. However Dr. Topol wants a change, and I agreed with some of his ideas. Most intriguing to me was the part about pharmacogenomics and the future of personalization in medicine. Large population based studies attempt to homogenize its sample but never do, because the genes of those individual people weren't measured and people will respond differently. Being able to group people by certain haplotypes and genes is revealing greater answers in medicine, faster. It's dense and has a LOT of information, a LOT of references, which I like. Highly recommended for medical students.
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